硕士生导师

    • 姓名:张弦
    • 职务:
    • 职称:副教授、硕导
    • 所属系:食品科学与工程系
    • 邮箱:zhangxian@hfut.edu.cn; zhangxian0426@hotmail.com
    • 办公地点:食生楼505
  • 个人简介
  • 研究领域
  • 科研项目
  • 学术成果
  • 荣誉奖项

学习经历:

2013.09-2016.06胸前的小兔子立起来,食品科学与工程,博士

2010.09-2013.06胸前的小兔子立起来,生物学,硕士

2006.09-2010.06安徽师范大学生命科学学院,生物科学,学士

工作经历:

2021.12-至今 胸前的小兔子立起来,副教授

2016.10-2021.10美国哈佛大学医学院,博士后

职务: 职称: 副教授、硕导
所属系: 食品科学与工程系 邮箱: zhangxian@hfut.edu.cn; zhangxian0426@hotmail.com
办公地点: 食生楼505 学术成果 <br>代表性论文:<br>
<br>1.Zhang X#(第一作者), Luo S, Wang M, Huang Q, Fang W, Li J, Liu T, Zhang Y, Deng Z, Liu CL, Guan S, Ayala JE, Flavell RA, Kulkarni RN, Libby P, Guo J*, Liu Z* and Shi GP*. IL18 signaling causes islet beta cell development and insulin secretion via different receptors on acinar and beta cells. Developmental Cell. 2022;57(12):1496-511 e6. 2<br>
<br>2.Zhang X#(第一作者), Luo S#, Wang M, Cao Q, Zhang Z, Huang Q, Li J, Deng Z, Liu T, Liu CL, Meppen M, Vromman A, Flavell RA, Hotamisligil GS, Liu J, Libby P, Liu Z* and Shi GP*. Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation. Nature Communications. 2022;13(1):7582.<br>
<br>3.Wang J#, Zhang Z, Lin Y, Chen J, Wang F, Wang L, Liu J*, Zhang X*(通讯作者). Diet Supplementation of Luteolin before Fatty Liver Formation Improves Hepatic Steatosis in Obese Mice by Inhibiting Visceral Adipose Tissue Lipolysis. Molecular Nutrition & Food Research. 2023, e2200478.<br>
<br>4.Zhang Z#, Wang J, Lin Y, Chen J, Liu J*, and Zhang X*(通讯作者). Nutritional activities of luteolin in obesity and associated metabolic diseases: an eye on adipose tissues. Critical Reviews in Food Science and Nutrition. 2022:1-15.<br>
<br>5.Zhang Y#, Liu T#, Deng Z#, Fang W#, Zhang X#(第一作者), Zhang S, Wang M, Luo S, Meng Z, Liu J, Sukhova GK, Li D, McKenzie ANJ, Libby P, Shi GP*, Guo J*. Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils. Advanced Science, 2023, 10(7): e220695.(中科院1区Top,影响因子17.521)<br>
<br>6.Zhang X#(第一作者), Li J, Luo SY, Wang MJ, Huang Q, Deng ZY, Febbo C, Daoui A, Liew PX, Sukhova GK, Metso J, Jauhiainen M, Shi GP*, Guo JL*. IgE contributes to atherosclerosis and obesity by affecting macrophage polarization, macrophage protein network, and foam cell formation. Arteriosclerosis Thrombosis and Vascular Biology. 2020;40: 597-610. 23<br>
<br>7.Zhang X#(第一作者), Wang X#, Yin H, Zhang L, Feng A, Zhang QX, Lin Y, Bao B, Hernandez LL, Shi GP*, Liu J*. Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice. Cell Reports. 2019;28(3): 792-803. 40<br>
<br>8.Zhang X#(第一作者), Zhou Y#, Yu X, Huang Q, Fang WQ, Li J, Bonventre JV, Sukhova GK, Libby P, Shi GP*. Differential roles of cysteinyl cathepsins in TGF-β signaling and tissue fibrosis. iScience. 2019;19: 607-622. 18<br>
<br>9.Zhang X#(第一作者), Huang Q#, Wang X, Deng Z, Li J, Yan X, Jauhiainen M, Metso J, Libby P, Liu J*, Shi GP*. Dietary cholesterol is essential to mast cell activation and associated obesity and diabetes in mice. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2019;1865(6):1690-1700. 14<br>
<br>10.Zhang X#(第一作者), Luo SY, Wang MJ, Shi GP*. Cysteinyl cathepsins in cardiovascular diseases. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 2020;1868(4):140360. 10<br>
<br>11.Zhang X#(第一作者), Zhang QX, Wang X, Zhang L, Qu W, Bao B, Liu CA, and Liu J*. Dietary luteolin activates browning and thermogenesis in mice through an AMPK/PGC1alpha pathway-mediated mechanism. International Journal of Obesity. 2016;40(12): 1841-1849. 86<br>
<br>12.Dong J#, Zhang X#(第一作者), Zhang L, Bian HX, Xu N, Bao B, and Liu J. Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKalpha1/SIRT1. Journal of Lipid Research. 2014;55(3):363-374.<br>
<br>13.Zhao L#, Zheng M, Cai H, Chen J, Lin Y, Wang F, Wang L, Zhang X, and Liu J*. The activity comparison of six dietary flavonoids identifies that luteolin inhibits 3T3-L1 adipocyte differentiation through reducing ROS generation. The Journal of Nutritional Biochemistry. 2022;112:109208.<br>
<br>14.Zhou Z#, Chen J*, Zhang ZX, Wang FB, Wang L, Lin Y, Zhang X, and Liu J*. Solubilization of luteolin in PVP40 solid dispersion improves inflammation-induced insulin resistance in mice. European Journal of Pharmaceutical Sciences. 2022;174:106188.<br>
<br>15.Li J#, Chen J, Wang L, Lin Y, Zhang X, Liu J*, and Wang F*. Characterization of the response of Escherichia coli to l-fucose in bacterial swimming motility. Journal of Basic Microbiology. 2022;62(5):584-92.<br>
<br>16.Liu CL#, Zhang X, Liu J, Wang Y, Sukhova GK, Wojtkiewicz GR, Liu T, Tang R, Achilefu S, Nahrendorf M, Libby P, Guo J, Zhang J*, and Shi GP*. Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis. Nature Communications. 2019;10(1):3978.<br>
<br>17.Liu CL#, Ren JY, Wang YZ, Zhang X, Sukhova GK, Liao M, Santos M, Luo S, Yang D, Xia M, Inouye K, Hotamisligil GS, Lu G, Upchurch GR, Libby P, Guo J, Zhang J*, and Shi GP*. Adipocytes promote interleukin-18 binding to its receptors during abdominal aortic aneurysm formation in mice. European Heart Journal. 2019;ehz856.<br>
<br>18.Li J#, Deng Z#, Zhang X, Liu F, Yang C, and Shi GP*. Deficiency of immunoglobulin E protects mice from experimental abdominal aortic aneurysms. The FASEB Journal. 2020;34:3091-3104.<br>
<br>19.Wang Y#, Liu CL, Fang W, Zhang X, Yang C, Li J, Liu J, Sukhova GK, Gurish MF, Libby P, Shi GP*, and Zhang J*. Deficiency of mouse mast cell protease 4 mitigates cardiac dysfunctions in mice after myocardium infarction. Biochimica et Biophysica Acta (BBA) - Molecular Basis of <br><br>20.Fang W#, He A#, Xiang MX, Lin Y, Wang Y, Li J, Yang C, Zhang X, Liu CL, Sukhova GK, Barascuk N, Larsen L, Karsdal M, Libby P, and Shi GP*. Cathepsin K-deficiency impairs mouse cardiac function after myocardial infarction. Journal of Molecular and Cellular Cardiology. 2019;127:44-56.<br>
<br>21.Liu CL#, Guo J#, Zhang X, Sukhova GK, Libby P, and Shi GP*. Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials. Nature Reviews Cardiology. 2018;15(6):351-370.<br>
<br>22.Zhang L#, Han YJ, Zhang X, Wang X, Bao B, Qu W, and Liu J*. Luteolin reduces obesity-associated insulin resistance in mice by activating AMPKalpha1 signaling in adipose tissue macrophages. Diabetologia. 2016;59(10):2219-2228.<br>
<br>23.Xu N#, Zhang L#, Dong J, Zhang X, Chen YG, Bao B, and Liu J*. Low-dose diet supplement of a natural flavonoid, luteolin, ameliorates diet-induced obesity and insulin resistance in mice. Molecular Nutrition & Food Research. 2014;58(6):1258-1268.<br>
研究领域 <br>1.糖脂代谢的免疫调控机制
以IL18信号通路和肥大细胞为对象,研究脂肪组织、胰腺等糖脂代谢稳态调控组织中细胞间的互作模式和信息交流机制。
<br>2.肥胖和相关代谢疾病(糖尿病、心血管疾病等)的免疫-代谢调控
基于糖脂代谢的免疫调控机制,探究该机制在肥胖和相关代谢疾病中发挥的作用。
<br>3.细胞代谢稳态的营养调控
基于IL18信号通路和肥大细胞的活性,研究黄酮类等生物活性物质对细胞代谢稳态的调控、对肥胖和相关代谢疾病的干预作用。
<br>欢迎生物学、生物工程、食品科学与工程、食品工程等专业学生报考。
科研项目 <br>1.国家自然科学基金青年项目:IL18作为棕色脂肪因子通过NCC调控机体能量代谢的机制研究(项目号32200630),2023.01-2025.12,主持人。
<br>2.合肥工业大学人才引进项目:IL18和MC调控肥胖及相关代谢疾病的机制研究(项目号13020-03712022006),2022.3-2025.3,主持人。
<br>3.海南医学院急救与创伤研究教育部重点实验室开放基金:半胱氨酸组织蛋白酶调节急性肾损伤的机制研究(项目号KLET-202119),2022.01 -2023.12,主持人。
<br>4.美国心脏协会American Heart Association (AHA) post-doctoral fellowship:Role of subcutaneous fat mast cells in adipose tissue thermogenesis and systemic energy expenditure (项目号18POST34050043),2018.07-2020.06,主持人。
荣誉奖项 <br>1.荣誉、奖励
<br>1)2023年安徽省青年“百人计划”
<br>2)2022年安徽省高层次创新创业人才
<br>3)合肥工业大学“黄山学者”学术骨干
<br>4)2015年博士研究生国家奖学金

<br>2.社会兼职
<br>1)《Frontiers in Immunology》客座编辑
<br>2)《Cell Reports》审稿人

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