硕士生导师

    • 姓名:徐建国
    • 职务:
    • 职称:副教授、硕导
    • 所属系:药物科学与工程系
    • 邮箱:jgxu0816@163.com
    • 办公地点:食生楼612
  • 个人简介
  • 研究领域
  • 科研项目
  • 学术成果
  • 荣誉奖项

学习经历:

2012年9月-2017年6月 福州大学 生物化工 博士

2008年9月-2012年6月 阜阳师范大学 材料化学 学士

工作经历:

2019年12月-至今 合肥工业大学,食品与生物工程学院,副教授,硕士生导师

2019年1月-2022年3月  合肥工业大学,食品与生物工程学院博士后

2017年6月-2019年12月 合肥工业大学,食品与生物工程学院,讲师,硕士生导师

职务: 职称: 副教授、硕导
所属系: 药物科学与工程系 邮箱: jgxu0816@163.com
办公地点: 食生楼612 学术成果 <br>代表性论文<br>
<br>1.Xinlei Zhang, Yubo Peng, Li Yao, Huijie Shang, Zhi Zheng, Wei Chen*, and Jianguo Xu*. Self-assembly of a multivalent aptamer-tethered DNA monolayers dedicated to a fluorescence polarization-responsive circular isothermal strand displacement amplification for Salmonella assay. Analytical Chemistry. 2023, 95, 2570−2578.<br>
<br>2.Huo Xu, Yanhui Zheng, Danlong Chen, Yinghao Cheng, Xiaojun Fang, Chunlian Zhong, Xinmei Huang, Qi Huang, Jiawei Xu, Jianguo Xu*, and Chang Xue*. A Branch-Shaped Trapping Device Regulates Accelerated Catalyzed Hairpin Assembly and Its Application for MicroRNA in Situ Imaging. Analytical Chemistry. 2023, 95, 1210−1218.<br>
<br>3.Huijie Shang, Yubo Peng, Li Yao, Zhi Zheng, Hongxia Li, Wei Chen*, Jianguo Xu*. Self-customized multi-channel exponential amplifications regulate powered monitoring of terminal deoxynucleotidyl transferase activity. Analytical Chemistry. 2022, 94, 32, 11401–11408.<br>
<br>4.Jianguo Xu*, Xinlei Zhang, Chao Yan, Panzhu Qin, Li Yao, Qi Wang, Wei Chen*. Trigging isothermal circular amplification-based tuning of rigorous fluorescence quenching into complete restoration on a multivalent aptamer probe enables ultrasensitive detection of Salmonella. Analytical Chemistry. 2022, 94, 2, 1357–1364.<br>
<br>5.Jie Wang Jie, Jiayin Sun, Jing Zhang, Chenlin Shen*, Xinlei Zhang, Jianguo Xu*. Engineered G-quadruplex-embedded self-quenching probes regulate single probe-based multiplex isothermal amplification to light road lamp probes for sensitized determination of microRNAs. Analytical Chemistry, 2022, 94, 10, 4437–4445<br>
<br>6.Juan Xia, Zhaoqiang Liu, Shulin Gao, Wenyong Li, Qi Wang*, Jianguo Xu*, Hai Wu*. Intermolecular and intramolecular priming co-directed synergistic multi-strand displacement amplification empowers ultrasensitive determination of microRNAs. Analytical Chemistry. 2022, 94, 16132−16141.<br>
<br>7.Jianguo Xu#, Chao Yan#, Xinxin Wang, Bangben Yao, Jianfeng Lu, Guodong Liu*, Wei Chen*. Ingenious design of DNA concatamers and G-quadruplex wires assisted assembly of multi-branched DNA nanoarchitectures for ultrasensitive biosensing of miRNA. Analytical Chemistry, 2019, 91: 9747-9753<br>
<br>8.Xinlei Zhang, Jianguo Xu*, Chao Yan, Li Yao, Huijie Shang, Wei Chen*. Short- and long-range FRET co-functionalized fluorescence quenching collapsar probe regulates amplified and accelerated detection of Salmonella. Journal of Agricultural and Food Chemistry. 2021, 69, 14294−14301<br>
<br>9.Wei Chen, Jun Teng, Li Yao, Jianguo Xu*, and Guodong Liu. Selection of specific DNA aptamers for hetero-sandwich based colorimetric determination of Campylobacter jejuni in food. Journal of Agricultural and Food Chemistry. 2020, 68, 31, 8455–8461<br>
<br>10.Jianguo Xu*, Zhi Li, Yumei Li, Yusheng Lu, and Jie Wang*. Activation of palindromes on a degradable modular grafting probe enables ultrasensitive detection of microRNAs. Chemical Communications, 2021, 57, 5941-5944<br>
<br>11.Jie Wang, Shuhui Li, Jianguo Xu*, Yusheng Lu, Min Lin, Chaihung Wang, Chen Zhang, Guoxing Lin, Lee Jia*. Functionalized dumbbell probe-based cascading exponential amplification DNA machine enables amplified probing of microRNAs. Chemical Communications, 2020, 56, 1681-1684<br>
<br>12.Panzhu Qin, Li Yao, Jianguo Xu*, Guodong Liu, Wei Chen*. Smart engineering of a dual-DNA machine with a high signal-to-noise ratio for one-pot robust and sensitive miRNA signaling. Chemical Communications, 2019,55, 14367-14370<br>
<br>13.Jianguo Xu, Zai-Sheng Wu*, Zhenmeng Wang, Jingqing Le, Tingting Zheng, Lee Jia*. Autonomous assembly of ordered metastable DNA nanoarchitecture and in situ visualizing of intracellular microRNAs, Biomaterials, 2017, 120: 57-65<br>
<br>14.Jianguo Xu, Zai-Sheng Wu*, Zhenmeng Wang, Hongling Li, Jingqing Le, and Lee Jia*, Two-wheel drive-based DNA nanomachine and its sensing potential for highly sensitive analysis of cancer-related gene, Biomaterials, 2016, 100: 110-117<br>
<br>15.Xinlei Zhang, Jianguo Xu*, Xiuguang Xing, Li Yao, Huijie Shang, Wei Chen*. Framework nucleic acid-wrapped protein-inorganic hybrid nanoflowers with three-stage amplified fluorescence polarization for terminal deoxynucleotidyl transferase activity biosensing. Biosensors and Bioelectronics, 2021, 193: 113564 <br>
<br>16.Wei Chen, Chao Yan, Lin Cheng, Li Yao, Feng Xue, Jianguo Xu*. An ultrasensitive signal-on electrochemical aptasensor for ochratoxin A determination based on DNA controlled layer-by-layer assembly of dual gold nanoparticle conjugates, Biosensors and Bioelectronics, 2018,117: 845–851<br>
<br>17.Jianguo Xu, Zai-Sheng Wu*, Weiyu Shen, Jingqing Le, Tingting Zheng, Hongling Li, Lee Jia*. Programmable nanoassembly consisting of two hairpin-DNAs for p53 gene determination, Biosensors and Bioelectronics, 2017, 94: 626-631<br>
<br>18.Jianguo Xu, Zai-Sheng Wu*, Hongling Li, Zhenmeng Wang, Jingqing Le, Tingting Zheng, Lee Jia*. Dual-cyclical nucleic acid strand-displacement polymerization based signal amplification system for highly sensitive determination of p53 Gene, Biosensors and Bioelectronics, 2016, 86: 1024-1030<br>
<br>19.Jianguo Xu#, Jun Qian#, Hongling Li, Zai-Sheng Wu*, Weiyu Shen, Lee Jia*, Intelligent DNA machine for the ultrasensitive colorimetric detection of nucleic acids, Biosensors and Bioelectronics, 2016, 75: 41-47<br>
<br>20.Jianguo Xu, Haiyan Dong, Weiyu Shen, Sudan He, Hongling Li, Yusheng Lu, Zai-Sheng Wu*, Lee Jia*. New molecular beacon for p53 gene point mutation and significant potential in serving as the polymerization primer, Biosensors and Bioelectronics, 2015, 66: 504-511<br>
<br>21.Jianguo Xu, Zai-Sheng Wu*, Weiyu Shen, Huo Xu, Hongling Li, Lee Jia*. Cascade DNA nanomachine and exponential amplification biosensing, Biosensors and Bioelectronics, 2015, 73: 19-25<br>
<br>22.Yubo Peng, Huijie Shang, Zhi Zheng, Hongxia Li, Wei Chen*, and Jianguo Xu*. Self-activation of symbiotic multi-DNA machines transducing exponentially amplified fluorescence for ultrasensitively signaling of terminal deoxynucleotidyl transferase activity. Sensors & Actuators: B. Chemical, 2023, 380, 133400 <br>
<br>23.Xinlei Zhang, Jianguo Xu*, Yubo Peng, Xinxin Wang, Huijie Shang, Li Yao, and Wei Chen* Dual-palindrome chained reaction regulates the formation of palindromic DNAzyme wire transducers empowering sensitized and one-step copper ion- dependent assay. Sensors & Actuators: B. Chemical, 2022, 370, 132471<br>
<br>24.Yinhuan Wu, Zhen Zeng, Ting Zhang, Chengxin Liu, Jianguo Xu*, Ruijie Deng, Qi Wang, and Feng Lin*. Synergetic dual-toehold mediated controllable transcription amplification for detecting lung cancer-related circulating miRNAs in blood. Sensors & Actuators: B. Chemical, 2022, 354, 131244<br>
<br>25.Qi Wang #, Wenyong Li #, Juan Xia, Hai Wu, Lijun Wu*, Jianguo Xu*. Stepwise tuning of a molecular beacon coupled Y probe regulates ternary DNA nanomachine-based microRNA determination. Sensors & Actuators: B. Chemical, 2022, 363, 131858<br>
<br>26.Xiaoming Ma, Shan He, Huifang Zhang, Xun Li*, Jun Xue, Xiaolin Fan, Yusheng Lu, Yiting Chen, Yanjie Zhang, and Jianguo Xu*. Delayed full opening of bumped switchable molecular probe enables repeated generation of target analogues for mix-to-signaling determination of microRNAs. Sensors & Actuators: B. Chemical, 2021, 327: 128875-128881<br>
<br>27.Wei Chen*, Fen Cai, Qian Wu, Yuhan Wu, Bangben Yao, and Jianguo Xu*. Prediction, evaluation, confirmation, and elimination of mat. rix effects for lateral flow test strip based rapid and on-site detection of aflatoxin B1 in tea. Food Chemistry. 2020, 328, 127081 <br>
<br>28.Xiaoming Ma, Zhen Wang, Xuan Hu, Jinghua Chen, Huifang Zhang, Xun Li, Fengyan Xie, Jianguo Xu*. Nanozyme catalysis-powered portable mini-drainage device enables realtime and universal weighing analysis of silver ions and silver nanoparticles. Journal of Hazardous Materials, 2021, 415, 125689.<br>
<br>29.Wei Chen*, Lijun Yang, Chao Yan, Bangben Yao, Jian-feng Lu, Jianguo Xu*, and Guodong Liu*. Surface-confined building of Au@Pt-centered and multi-G-quadruplex/hemin wires-surrounded electroactive supernanostructures for ultrasensitive monitoring of morphine. ACS Sensors. 2020, 5, 8, 2644–2651<br>
<br>30.Xiuguang Xing, Li Yao, Chao Yan, Zhenlin Xu, Jianguo Xu*, Guodong Liu*, Bangben Yao*, and Wei Chen*. Recent progress of personal glucose meters integrated methods in food safety hazards detection. Critical Reviews in Food Science and Nutrition. 2022, 62(27): 7413-7426.<br>

<br>专利
<br>1.徐建国; 陈伟; 闫超; 秦盼柱; 姚丽;一种检测microRNA-21的电化学传感器、其制备方法及应用; 2018-12-13, 中国专利, CN201811523457.5 (授权)<br>
<br>2.徐建国; 陈伟; 秦盼柱; 闫超; 张超; 王昕昕; 高岩;2019-04-11, 中国专利,一种双重DNA机器检测microRNA-21的方法,CN201910288202.3;(授权)<br>
<br>3.徐建国; 陈伟; 张鑫磊;2022-10-25,中国专利,一种功能性核酸探针及其制备方法与应用,CN202211312408.3<br>
<br>著作
<br>1.《食品安全学》,郑州大学出版社,编委,2019年12月<br>
<br>2.Jianguo Xu, Li Yao, Lin Cheng, Chao Yan, and Wei Chen*. “Development of Aptamer-Based Electrochemical Methods.” Aptamers for Analytical Applications: Affinity Acquisition and Method Design, Willey publishing, 2018: 247-271.
研究领域 <br>1.食品安全危害因子/疾病标志物分子检测技术的基础和应用研究
<br>(1)核酸分子扩增传感原理与技术构建
<br>(2)框架核酸组装与纳米传感技术构建
<br>(3)侧向层析快速检测技术基础与应用研究
科研项目 <br>1.国家自然科学基金青年基金项目,21804028,2019.01-2021.12,项目主持人,结题;
<br>2.安徽省重点研发计划项目,202004h07020029,2020.01-2022.12,项目主持人,在研;
<br>3.安徽省重点研发计划项目,202104a07020008,2021.1-2023.12,项目子课题主持人,在研;
<br>4.    安徽省重点研发计划项目,2022e07020060,2022.1-2024.12,项目子课题主持人,在研;
<br>5.    安徽省自然科学基金青年基金项目,1908085QC121,2019.07-2021.06,项目主持人,在研;
<br>6.    中国博士后基金面上项目,2019M652167,2019.06-2021.01,项目主持人,结题
荣誉奖项

上一条:吴学凤 下一条:徐红梅

关闭

电话:0551-62901285邮箱:spxy@hfut.edu.cn

邮编:230601版权所有:胸前的小兔子立起来狂飙网站 - 蜜叶百科网

扫一扫

学院官方公众号